Day One
Wednesday, December 11
8:00 am Registration & Morning Refreshments
8:50 am Chair’s Opening Remarks
Identifying Applications for Discovery & Engineering to Prioritize With Efficiency
9:00 am Fireside Chat: Weighing Up Benefits-Costs for Investment in Prediction Tools to Understand Potential vs Risk
Synopsis
• Evaluating prediction tool benefits to understand accelerated discovery effects
• Pin-pointing prediction tool limitations to understand overreliance risks and lack of flexibility issues
• Identifying how to mitigate associated prediction tool risks to decipher whether or not to invest
9:45 am Case Study: Optimizing Enzyme Engineering for a Cascade Reaction to Facilitate API Production
Synopsis
• Understanding how to develop enzymes accounting for substrate load and flexibility for a successful biocatalysis process
• Overcoming enzyme development challenges to obtain desired engineering outcomes
• Leveraging elements of ML to accelerate enzyme engineering
Visualizing Upstream & Downstream Processes With a New Lens to Optimize End-to-End Process Efficiencies
10:15 am Tapping into Cascade Reactions for APIs to Minimize Waste & Support Green Chemistry
Synopsis
• Undertaking precision selection during engineering to promote enzyme compatibility with operating conditions
• Optimizing enzyme concentrations and reaction conditions to minimize the inhibition challenge
• Enabling coupled enzyme reactions to enable co-factor regeneration and streamline the cascade reaction
10:45 am Speed Networking & Morning Refreshments
Synopsis
Join our speed networking session to meet everyone in the room during a morning
refreshment period
11:45 am Futureproofing Early-Stage Scale up to Secure Optimal Synthesis Routes for Maximal End-Product Yields
Synopsis
• Making small-scale assessments to enable selectivity on a molecular scale
• Conducting small-scale synthesis planning to move forward with the most optimal biocatalysis routes
• Discovering routes for small and large scale and factoring in reproducibility and consistency
12:15 pm Case-Study: Uncovering Novo Nordisk’s Approach to Revolutionizing Oligonucleotide Production Via Biocatalysis & Observing Reactogenicity – Pharma Applications
Synopsis
• Implementing process efficiency for complex modalities and considering new developments for oligonucleotides to support biocatalysis optimization
• Synthesising shorter fragments during engineering to contribute towards sustainability and productivity of biocatalysis
• Hybridizing the oligonucleotide biocatalysis approach to maintain and maximize efficiency and yield
12:45 pm Networking Lunch
Narrowing Down Enzyme Variations Using Advanced Throughput Tools to Select for Flexibility
1:45 pm Identifying Non-Traditional Enzyme Engineering Capabilities to Improve Substrate Flexibility
Synopsis
• Exploring the technicalities of enzyme design for unconventional reactions to produce small molecules
• Pin-pointing optimal design principles during engineering to streamline early-stage success
• Understanding early conceptual framing to introduce non-conventional biocatalysis design
2:15 pm Roundtable Discussion: Identifying How to Optimize Enzyme Prioritization to Streamline Biocatalysis
Synopsis
• What are the key enzyme prioritization principles important to future-proof biocatalysis?
• How to advance current throughput screening methods for more efficient enzyme decision-making?
• What are the bottlenecks being faced regarding enzyme prioritization?
3:00 pm Afternoon Break & Poster Session
Synopsis
Take part in this opportunity to present your recent work in the field, hear feedback and gain inspiration from industry pioneers in the room
Identifying Novel & Sophisticated Engineering Efforts With Industrial Promise for Small & Large Molecule Development
3:45 pm Case Study: Utilizing Computation in Engineering With Mutexa to Navigate the Large Design Landscape & Inform Engineering
Synopsis
• Leveraging automated workflows to allow computation-aided enzyme engineering to minimize time pressures and boost efficiency
• Exploring effective engineering efforts to allow enzymes to flourish at lower temperatures to decrease cost and environmental pressures
• Identifying emerging opportunities for engineering with computation to future-proof biocatalysis-informed drug development