Day One
Wednesday, November 12
8:00 am Registration & Coffee
8:50 am Chair’s Opening Remarks
Unlocking the Full Potential of Biocatalysis to Drive Sustainable, Cost-Effective & Scalable Innovation
9:00 am Fireside chat: Reviewing the Landscape of Biocatalysis & Overcoming Common Pitfalls Together
Synopsis
This is your opportunity to ask your questions directly to those leading the implementation of biocatalysis. Hear from experts at companies at various stages along this journey and learn from their experience to accelerate your own progress.
- Understanding common hurdles companies face in committing resources and expertise to biocatalysis
- Highlighting strategies to simplify implementation with minimal investment and focused expertise
- Exploring how lowering the barrier to entry can accelerate broader adoption and innovation
9:45 am Next Generation Manufacturing Process for siRNA
Synopsis
- Developing efficient and scalable biocatalytic processes for oligonucleotide manufacturing
10:15 am Provolut – AI Next Gen Designer Enzymes
Synopsis
- Designing enzymes for enzymatic API production – KRED and IRED
- ADC conjugation enzymatic amide bond formation
- Designing enzymatic split systems – enabling therapeutics for AND gate dual targeting
- Designing production cascades – amide and peptide bond formation
10:45 am Applying Enzymatic Ligation to Oligonucleotide Synthesis: Reducing the Need for Purification with More Selective Biocatalysis
Synopsis
- Minimizing unwanted byproducts of biocatalysis to lower costs and simplify downstream processing
- Creating safer and cleaner outcomes through innovative enzyme engineering strategies
- Outlining steps to obtain regulatory approvals for new processes
11:15 am Morning Break & Speed Networking
Synopsis
Elevate your networking experience by joining the speed networking session tailored for biocatalysis and enzyme engineering experts, like yourselves, to connect with industry peers and facilitate rapid yet meaningful exchanges of insights and expertise.
Utilizing Biocatalysis to Create More Sustainable Processes
12:15 pm Roundtable Discussion: Aligning Sustainability Metrics and Defining New Targets for Biocatalysis
Synopsis
- Cutting waste with enzyme-driven processes that align with net zero goals
- Swapping solvents for water to boost sustainability without sacrificing performance
- Demystifying sustainability metrics to guide better pharma decision-making
12:45 pm RNA Synthesis Using Ligation for Improved Scalability & Reduced Manufacturing Cost
Synopsis
- Discuss siRNA synthesis by assembly of multiple short, single-stranded RNA fragments into the desired double-stranded RNA duplex using ligation.
- Compare various ligation approaches with a particular focus on substrate design. In combination with double-stranded RNA ligase engineering and protocol optimization, such integrated process development can increase target drug substance yield and reduce manufacturing costs.
- Process performance will be demonstrated on the synthesis of a commercially approved siRNA asset
1:15 pm Lunch Break
Navigating Biocatalysis Scale-Up by Balancing Speed, Risk & Process Integration
2:15 pm Building Smarter Biocatalysis Workflows for Speed & Scale
Synopsis
- Gaining a clear roadmap from enzyme discovery to large-scale with realistic and actionable timelines
- Avoiding critical delays by anticipating downstream processing challenges
- Balancing risk and investment in enzyme engineering during fast-moving early development
2:45 pm Moving from Route Design to Ton-Scale Production with Cost-Effective Whole-Cell Biocatalysts
Synopsis
- Enhancing biocatalyst performance quickly with AI-driven enzyme engineering
- Advancing chiral amine production with proven transaminase technology to expand versatility and performance.
2:55 pm Unlocking Faster Enzyme Optimization with Streamlined, Scalable Workflows
Synopsis
- Reducing enzyme optimization timelines through streamlined workflows from variants design and construction to testing
- Showcasing rapid, real-world case studies of efficient enzyme evolution and screening
- Utilizing cutting-edge molecular biology technologies to reduce the overall number of steps and minimize timelines
3:25 pm AI-Guided Biosynthesis Platform for Sustainable Active Pharmaceutical Ingredient (API) Production
Synopsis
- Presenting an AI Biosynthesis Route Planning System (ABRPS) to Optimize Pathways & Enzymes of Complex API/KSM Pathways
- Producing the API/KSM via a Multi-Enzyme Biocatalysis Sequence from Low-Cost, US Sourced Commodity Compounds
- Accelerating Discovery & Optimization with Our High-Throughput Enzyme-Screening Workflow
3:55 pm Poster Session & Afternoon Break
Bridging Medicinal & Process Chemistry to Break Down Silos & Accelerate Drug Development Timelines
5:00 pm Application of Biocatalysis Technology to the Unique Challenges of Early Medicinal Chemistry Programs
Synopsis
- Pioneering the integration of biocatalysis into medicinal chemistry by supporting project teams with practical, often scalable enzyme-based solutions
- Navigating limited timelines and resources by working primarily with commercially available enzymes, without intensive engineering
- Showcasing real-world case studies that highlight effective collaboration between teams to solve challenges and accelerate project timelines
5:30 pm Enzyme Engineering for More Efficient Cofactor Recycling
Synopsis
- This presentation we will compare the use of glucose vs. iPrOH for the regeneration of NAD(P)H cofactor on biocatalysed redox reactions.
- Moving from glucose to the more atom efficient iPrOH requires ADHs that are very active, stable and amenable to both NADH and NADPH. We will demonstrate how we have achieved this through enzyme engineering, following rational approaches to library design.
- For those occasions when glucose is preferable, we have designed GDH variants that can accept both cofactors while remaining active and stable.
5:40 pm Streamlining Drug Development by Embedding Biocatalysis Early
Synopsis
- Showcasing real-world case studies where biocatalysis delivered fast solutions under time pressure
- Enabling smoother tech transfer by implementing biocatalysis early in development
- Bridging med chem and process chem to accelerate route optimization and scale-up