Day One

Wednesday, November 12

8:00 am Registration & Coffee

8:50 am Chair’s Opening Remarks

Unlocking the Full Potential of Biocatalysis to Drive Sustainable, Cost-Effective & Scalable Innovation

9:00 am Fireside chat: Reviewing the Landscape of Biocatalysis & Overcoming Common Pitfalls Together

  • Michael Miller Principal Scientist, International Flavors & Fragrances
  • Jason Tedrow Global Head of Process Chemistry, Sanofi
  • Adrian Ortiz Executive Director, Process Research and Development, Eli Lilly & Co.
  • Amarjit Singh Associate Scientific Fellow, Takeda Pharmaceutical

Synopsis

This is your opportunity to ask your questions directly to those leading the implementation of biocatalysis. Hear from experts at companies at various stages along this journey and learn from their experience to accelerate your own progress.

  • Understanding common hurdles companies face in committing resources and expertise to biocatalysis
  • Highlighting strategies to simplify implementation with minimal investment and focused expertise
  • Exploring how lowering the barrier to entry can accelerate broader adoption and innovation

10:00 am Next Generation Manufacturing Process for siRNA

Synopsis

  • Developing efficient and scalable biocatalytic processes for oligonucleotide manufacturing

10:30 am Applying Enzymatic Ligation to Oligonucleotide Synthesis: Reducing the Need for Purification with More Selective Biocatalysis

Synopsis

  • Minimizing unwanted byproducts of biocatalysis to lower costs and simplify downstream processing
  • Creating safer and cleaner outcomes through innovative enzyme engineering strategies
  • Outlining steps to obtain regulatory approvals for new processes

11:00 am Morning break & Speed Networking

Synopsis

Elevate your networking experience by joining the speed networking session tailored for biocatalysis and enzyme engineering experts, like yourselves, to connect with industry peers and facilitate rapid yet meaningful exchanges of insights and expertise.

Utilizing Biocatalysis to Create More Sustainable Processes

12:00 pm Roundtable Discussion: Aligning Sustainability Metrics and Defining New Targets for Biocatalysis

  • Erin Obrien Head of Process Chemistry, Synthetic Molecule Process Development, Takeda Pharmaceutical

Synopsis

  • Cutting waste with enzyme-driven processes that align with net zero goals
  • Swapping solvents for water to boost sustainability without sacrificing performance
  • Demystifying sustainability metrics to guide better pharma decision-making

12:30 pm Session reserved for Codexis

1:00 pm Lunch Break

Navigating Biocatalysis Scale-Up by Balancing Speed, Risk & Process Integration

2:00 pm Building Smarter Biocatalysis Workflows for Speed & Scale

Synopsis

  • Gaining a clear roadmap from enzyme discovery to large-scale with realistic and actionable timelines
  • Avoiding critical delays by anticipating downstream processing challenges
  • Balancing risk and investment in enzyme engineering during fast-moving early development

2:30 pm Unlocking Faster Enzyme Optimization with Streamlined, Scalable Workflows

Synopsis

  • Reducing enzyme optimization timelines through streamlined workflows from variants design and construction to testing
  • Showcasing rapid, real-world case studies of efficient enzyme evolution and screening
  • Utilizing cutting-edge molecular biology technologies to reduce the overall number of steps and minimize timelines

3:00 pm Session reserved for Kaneka North America

3:30 pm Poster Session & Afternoon Break

Bridging Medicinal & Process Chemistry to Break Down Silos & Accelerate Drug Development Timelines

4:30 pm Application of Biocatalysis Technology to the Unique Challenges of Early Medicinal Chemistry Programs

Synopsis

  • Pioneering the integration of biocatalysis into medicinal chemistry by supporting project teams with practical, often scalable enzyme-based solutions
  • Navigating limited timelines and resources by working primarily with commercially available enzymes, without intensive engineering
  • Showcasing real-world case studies that highlight effective collaboration between teams to solve challenges and accelerate project timelines

5:00 pm Streamlining Drug Development by Embedding Biocatalysis Early

Synopsis

  • Showcasing real-world case studies where biocatalysis delivered fast solutions under time pressure
  • Enabling smoother tech transfer by implementing biocatalysis early in development
  • Bridging med chem and process chem to accelerate route optimization and scale-up

5:30 pm End of Conference Day One