Thursday, November 13
8:00 am Coffee & Networking
8:50 am Chair’s Opening Remarks
Driving Faster Enzyme Engineering & Smarter Decisions with AI Innovations
9:00 am Roundtable Discussion: Making Sense of AI in Biocatalysis Today & Setting Priorities for Tomorrow
Synopsis
- Examining the current limitations and challenges in AI methods for enzyme and protein design
- Exploring how companies are overcoming hurdles to make AI more practical and predictive
- Assessing the real-world viability of AI technologies and identifying next steps for advancement
9:30 am ScalaOS: Optimizing Enzyme Activity, Selectivity, & Stability Through Computational Design
Synopsis
- ScalaOS demonstrated major gains in stability, activity, selectivity, and expression through one design round and with no tradeoffs.
- ScalaOS is an intuitive, no-code interface that enables adoption by both computational and experimental enzyme engineers.
- Scala’s technologies have been adopted by leading pharma and chemical companies and validated in 130+ publications and collaborations worldwide.
10:00 am Morning Break & Networking
Exploring Untapped Enzymes & Improving Engineering Success to Enhance Industrial Biocatalysis
11:00 am Exploring Untapped Enzyme Classes for New Industrially Relevant Reactions
Synopsis
- Expanding substrate scope to unlock reactivity in underexplored enzyme classes or clades
- Leveraging high-throughput screening and engineering to develop biocatalysts for industrial applications
11:30 am Digital Enzyme Evolution – A Deeply Integrated Workflow to Accelerate Enzyme Engineering
Synopsis
- Harnessing Digital Integration: combining AI-directed design, efficient biology and wet-lab automation, and data management in a seamless, digitalised workflow.
- Training AI on High-Quality Data: merging rapid physics-based modelling with rich experimental datasets to guide intelligent, predictive enzyme design.
- From Design to Demonstration: applying our efficient workflow to deliver significant performance gains in real-world enzyme case studies.
11:40 am Microheterogeneity on Enzyme: Formation, Analysis and Effects of Structural Variants
Synopsis
- Understanding common mechanisms that lead to microheterogeneity, such as post-translational modifications (PTMs), degradation and modifications by reactive metabolites and excipients
- Recognizing why microheterogeneity often goes undetected and learning analytical strategies to accurately assess protein quality
- Discussing strategies to improve the success of enzyme engineering efforts by controlling microheterogeneity
12:10 pm Lunch Break
Combining Biocatalysis & Chemical Catalysis to Expand Synthetic Capabilities
1:30 pm Biocatalytic & Chemo-Enzymatic Strategies to Access Novel Amino Acids & Medicinally Relevant Small Molecules
Synopsis
- Harnessing the unique selectivity of enzymes to solve longstanding challenges in chemical synthesis
- Leveraging recent breakthroughs in enzyme engineering and genome mining to unlock new synthetic possibilities
- Developing innovative hybrid strategies that integrate biocatalysis with modern chemical methodologies for the synthesis of noncanonical amino acids and medicinally relevant molecules
2:00 pm Bridging Biological and Chemical Approaches with Chemoenzymatic Catalysis
Synopsis
- Expanding the chemical space for synthetic co-factors and engineering enzymes to utilize these novel tools
- Integrating chemical and enzymatic catalysis to develop advanced chemoenzymatic pathways
- Bridging biocatalysis with applications in commodity chemicals and pharmaceuticals to achieve shared industrial goals
2:30 pm Afternoon Break & Networking
Advancing Biocatalytic Processes for Peptide Drugs Using Protein Engineering & Cascade Reactions
3:30 pm Protein Engineering Unlocks Biocatalytic Processes for a Peptide Drug
Synopsis
- Details TBC
4:00 pm A Scalable Enzyme Cascade for the Synthesis of Non-Canonical Amino Acids in Peptide Drug Development
Synopsis
- Developing a toolbox that allows for the rapid development of non-canonical amino acids
- Leveraging cascade reactions to yield time and cost savings
- Showcasing this reaction at the 50-100g scale