Thursday, December 12
8:30 am Registration & Morning Refreshments
9:20 am Chair’s Opening Remarks
Tapping into Cross-Modality Possibilities for Biocatalysis to Inspire Drug Development
9:30 am Design of Cell-Free & Cellular Biocatalytic Cascades to Produce Modality-Agnostic Building Blocks
Synopsis
• Harnessing enzyme promiscuity and biochemical pathway design to create platform transformations
• Description of nitrogenous functional group targets spanning amines, nitro compounds and non-standard amino acids
• Engineering bacterial cell lines to prevent undesired reactions for intermediates or products
10:00 am Roundtable Discussion: Are Biocatalysis Processes Always Greener?
Synopsis
• What are some points in favour for green biocatalysis processes?
• From discovery, engineering and biocatalysis, which point of the spectrum should green and economical drug development lie?
• Why may biocatalysis not be as green as may seem?
10:45 am Morning Refreshments & Networking
Contributing Towards Green Chemistry During Engineering to Accelerate Sustainable Efforts & Minimize Cost
11:30 am Merging Photochemistry & Biocatalysis Towards Making a Greener Process To Enhance Sustainable Efforts
Synopsis
• Discussing how merging two emerging technologies dramatically enhanced the overall eco-design for a complex small intermediate
• Exploiting unique and unexpected reactivity during the biotransformation to further refine the process metrics
• Optimizing engineering and identifying the potential for complex biologics to widen applications
12:00 pm Exploiting Process Development & Scale Up of an Enzymatic Dynamic Kinetic Resolution (DKR) as a Green Alternative
Synopsis
• Implementing high throughput and medium throughput experimentation to move towards scalability
• In depth media engineering to overcome limitations of ketoreductase catalyzed dynamic kinetic resolution
• Addressing scale up challenges and developing solutions to achieve robust processes
12:30 pm Networking Lunch
1:30 pm Case Study: Eradicating Bottlenecks of Cost & Sustainability to Optimize a Through Biocatalysis Discovery in Route Optimization
Synopsis
• Revamping an initial reaction route using biocatalysis to improve cost and sustainability
• Leveraging E-rad and K-rad ERED/KRED cascades to influence commercial routes
• Generating scaled data from batch production to streamline large-scale processes
Examining Industrialization Considerations from Discovery to Downstream Processing to Achieve Desired Large-Scale Outcomes
2:00 pm Considering End-to-End Workflow Operations to Futureproof Biocatalysis
Synopsis
• Addressing early-stage engineering considerations to prepare for later industrialization
• Creating a robust end-to-end biocatalysis strategy to streamline operations
• Optimizing the green chemistry approach for biocatalysis to enhance sustainability and minimize spend
2:30 pm Afternoon Networking
Pin-Pointing Desired Reactivity & Structure During Discovery to Futureproof Industrialization
3:00 pm Finding New Bioreactivity for Enzymes With Industry Potential to Identify Biotransformations of Future Promise
Synopsis
• Identifying novel enzymes in academia with industrial potential to understand how to overcome the application challenge
• Pin-pointing small-scale transformations to find new reactivities with revolutionary potential
• Facilitating decision-making between exploiting existing reactivity vs identifying new reactivities to set biocatalysis up for success
3:30 pm Exploring Selective C(sp3)-H Alkylation With Engineered Carbene Transferases
Synopsis
• Discussing how carbene transfer reactions represent a new class of transformations accessible via biocatalysis
• Exploring developed new engineered metalloenzymes for stereoselective functionalization of C(sp3)-H bonds via carbene transfer
• Considering applications for the late-stage functionalization of APIs and drug molecules