Pre-Conference Workshop Day

Tuesday, December 10

Workshop A | 9:00 – 12:00

9:00 am Delving Into Realistic & Transformative Enzyme Design Techniques to Revolutionize Biocatalysis-Informed Small & Large Molecule Development

Synopsis

Given the last 12-month pivot in the space and maturation of engineering technologies, senior enzyme engineering experts have now evolved their capabilities. With the biocatalysis toolbox being applied to more areas of the drug development portfolio than ever before, discover how process scientists can leverage bioinformatics and AI-assisted prediction to aid in streamlining development for novel applications.

• Outlining design-make-test-analyse cycles and how to incorporate the aid of computation for advanced efficiency

• Leveraging ML-informed feedback loops between design and test phases to ensure efficient design improvements are being made continuously

• Conducting structure-based, statistics-based, and AI-informed design techniques in conjunction to ensure experimental techniques align with technology development

Networking Lunch | 12:00-1:00

Workshop B | 1:00 – 4:00

1:00 pm Optimizing Process Efficiency for Hybrid Molecules to Enhance Biocatalysis Success Outcomes

  • Jan Grunewald Associate Director & Principal Scientist, AstraZeneca
  • Roumen Radinov VP Process Sciences, Alnylam Pharmaceuticals
  • Alain Rabion Head Of Development Vitry Biochemistry department, Sanofi

Synopsis

Join this workshop to assess industrialization potential for your enzymes and how to enhance process efficiencies during scale up to accelerate yields for small and large molecule development.

Leaders across process chemistry and biocatalysis are ready to dive into the computation-informed process and reactivity optimization to help you transform your biocatalysis-informed drug development.

• Identifying principles to optimize biocatalysis from early stage through to scale for modalities beyond small molecule

• Understanding potential for biocatalysis-derived large molecule development to understand effects on yield and downstream requirements

• Exploring biocatalysis in oligonucleotide process development for more efficient, scalable, and sustainable manufacture