RNA Synthesis Using Ligation for Improved Scalability & Reduced Manufacturing Cost
Time: 12:45 pm
day: Conference Day One
Details:
- Discuss siRNA synthesis by assembly of multiple short, single-stranded RNA fragments into the desired double-stranded RNA duplex using ligation.
- Compare various ligation approaches with a particular focus on substrate design. In combination with double-stranded RNA ligase engineering and protocol optimization, such integrated process development can increase target drug substance yield and reduce manufacturing costs.
- Process performance will be demonstrated on the synthesis of a commercially approved siRNA asset
