David Entwistle

Company: Codexis

Job title: Head of Process Chemistry

Seminars:

RNA Synthesis Using Ligation for Improved Scalability & Reduced Manufacturing Cost 12:45 pm

Discuss siRNA synthesis by assembly of multiple short, single-stranded RNA fragments into the desired double-stranded RNA duplex using ligation. Compare various ligation approaches with a particular focus on substrate design. In combination with double-stranded RNA ligase engineering and protocol optimization, such integrated process development can increase target drug substance yield and reduce manufacturing costs. Process…Read more

day: Conference Day One