Explore the Agenda
8:00 am Morning Coffee & Check-in
8:55 am Chair’s Opening Remarks
Scaling Up Biocatalysis, Overcoming Process, Cost & Enzyme Performance Barriers to Enable Industrial Deployment
9:00 am Unlocking Scalable Macrocyclic Peptide Production Through Integrated Biocatalysis
- Understand how engineered enzyme cascades were applied to overcome key manufacturing challenges associated with macrocyclic peptide synthesis
- Integrate biocatalysis, purification, and process development workflows to support large-scale industrial implementation
- Explore how scalable biocatalytic manufacturing platforms can accelerate future peptide and complex modality pipelines
9:30 am Session Reserved for Imperagen
9:40 am From In Silico to Industrial Reality, Translating AI-Designed Enzymes into Scalable, Functional Biocatalysts
- Understanding where AI-designed enzymes succeed and fail when translated into lab and industrial settings
- Identify key bottlenecks in experimental validation and how to overcome them
- Aligning computational predictions with real-world reaction conditions
10:10 am Morning Break & Networking
Early Adoption & Real-World Implementation, Embedding Biocatalysis Upstream to De-Risk Development & Accelerate Timelines
11:10 am Demonstrating the Value of Early Biocatalysis Adoption to Overcome Risk Aversion & Secure Internal Buy-In
- Learn how to position biocatalysis as a low-risk, high-impact strategy early in development
- Understand common barriers to adoption, including organization inertia and chemistry bias
- Explore approaches to justify early investment despite uncertain project outcomes
11:40 am Enabling Smarter Biocatalysis Through In-Situ Analytics & Kinetic Modelling for Real-Time Process Optimization
- Explore approaches to improve insight into biocatalytic reactions through enhanced data capture and analysis
- Understand how integrating experimental data with modelling can support more informed process optimization and decision-making
- Learn how developing a deeper understanding of reaction behaviour can reduce experimental burden and support more efficient scale-up
12:10 pm Panel: Embedding Biocatalysis Upstream, When Does It Add Value & How Do You Make It Stick?
- When is the right stage to introduce biocatalysis in the development pipeline?
- How are organizations balancing early investment with high attrition risk?
- What has worked (and failed) when trying to shift from late-stage to early-stage adoption?
- How do you align chemists, biologists, and process teams around a shared approach?
12:45 pm Lunch Break
Designing Smarter Bioprocesses, Harnessing Cascades, Cofactors, Immobilization & Novel Enzyme Classes for Maximum Efficiency
1:45 pm Optimizing Cofactor Usage & Regeneration to Reduce Cost & Enable Scalable Multi-Enzyme Systems
- Understand the impact of cofactor cost on overall process economics
- Explore strategies for cofactor recycling and regeneration in multi-step reactions
- Evaluate the potential of synthetic cofactors for improved stability and scalability
2:15 pm Beyond Ligation, Expanding the Biocatalytic Toolbox to Tackle Challenging Transformations in Complex Molecules
- Explore advances in enzyme ligation alongside emerging enzyme classes and reactions
- Understand how polymerases and other enzymes are being leveraged for new applications
- Learn how biocatalysis is enabling previously inaccessible or inefficient chemical transformations
Sustainability, Regulation & Strategic Alignment, Demonstrating Green Value While Navigating Evolving Regulatory Expectations
2:45 pm Green Chemistry Exchange Show, Tell & Steal
Bring your best sustainability wins, and your toughest challenges. In this interactive exchange, rotate through groups to share what’s working (and what’s not) in measuring the greenness of biocatalysis, and leverage fresh ideas from your peers.
3:30 pm Transformation of Aromatic Feedstocks into Value-Added Products via New-to-Nature Biocatalysis
- Discuss recent advances in applying enzyme engineering and biocatalysis to enable greener, more sustainable synthetic routes
- Highlight the potential of engineered biocatalysts for transforming inexpensive chemical feedstocks, including biomass-derived materials, into useful chemical products
- Showcase how new-to-nature biocatalysis can expand the reactivity of enzymes beyond those found in biology, enabling selective chemical transformations that are difficult to achieve using traditional synthetic methods